Actin draws a cadherin crowd
نویسندگان
چکیده
منابع مشابه
α-Catenin–mediated cadherin clustering couples cadherin and actin dynamics
The function of the actin-binding domain of α-catenin, αABD, including its possible role in the direct anchorage of the cadherin-catenin complex to the actin cytoskeleton, has remained uncertain. We identified two point mutations on the αABD surface that interfere with αABD binding to actin and used them to probe the role of α-catenin-actin interactions in adherens junctions. We found that the ...
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Cell-cell adhesion plays critical roles in establishing and maintaining tissue architecture and function (1,2). In these roles, cell-cell adhesion must be adaptable and, depending on the biological circumstance, weak, dynamic or strong. Different adhesion structures (adherens junctions, tight junctions, desmosomes) regulate cell-cell adhesion, and each comprises distinct membranebound adhesion ...
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Fat cadherins form a distinct subfamily of the cadherin gene superfamily, and are featured by their unusually large extracellular domain. In this work, we investigated the function of a mammalian Fat cadherin. Fat1 was localized at filopodial tips, lamellipodial edges, and cell-cell boundaries, overlapping with dynamic actin structures. RNA interference-mediated knockdown of Fat1 resulted in di...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2011iti3